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Is the vaccine safe? Yes, the vaccines that will be available to Oklahomans are safe and effective. The FDA (U.S. Food and Drug Administraton) has rigorous scientific and regulatory processes in place that ensure the safety, effectiveness and quality of COVID-19 vaccines. Throughout the entire process, the vaccines were evaluated for their safety and efficacy. Oklahomans should feel confident in receiving the vaccines. Both the Moderna vaccine and the Pfizer vaccine have been shown in late-stage vaccine trials to be safe and very effective, 94.5% and 95% effective, respectively. We encourage all Oklahomans to receive the vaccine when it becomes available to them.